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. Author manuscript; available in PMC: 2018 Mar 10.
Published in final edited form as: ACS Infect Dis. 2017 Feb 8;3(3):225–236. doi: 10.1021/acsinfecdis.6b00202

Scheme 2. Synthesis of the western end of dechloro-1 analogs.

Scheme 2

Reagents and conditions: (a) H2SO4, EtOH, reflux, o.n.; (b) methyl bromoacetate, K2CO3, DMF, rt, 3 hrs; (c) LiAlH4, THF, 0 °C, 30 min, rt, 1.5 hrs; (d) MnO2, CH2Cl2, rt, o.n.