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Wild-type and 1433-resistant T. brucei growth inhibition assays. EC50s represent averages and standard error of the mean of two independent assays.
| Strain | |||
|---|---|---|---|
| Compound | WT EC50 (nM) | 1433 resistant EC50 (nM) | 1433 resistant EC50 / WT EC50 |
| Pentamidine | 1.5 ± 0.2 | 1.1 ± 0.1 | 0.73 |
| 1433 | 98 ± 1 | 4700 ± 230 | 48 |
| 1 | 0.13 ± 0.01 | 14 ± 1 | 108 |
