Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam and betamethasone 17-valerate 2.25 mg (BV)-medicated plasters are efficacious and safe topical treatments for plaque psoriasis; the latter is also recommended for treating plaques localized on difficult-to-treat (DTT; elbow, knee, anterior face of the tibia) areas.

Cal/BD aerosol foam demonstrated significantly greater improvement in clinical signs of psoriatic plaques compared with BV-medicated plasters. Furthermore, Cal/BD aerosol foam was significantly more effective than BV-medicated plasters on DTT areas, as shown in post hoc analyses.

Cal/BD aerosol foam may provide a more successful treatment outcome in patients with plaque psoriasis than some of the currently available topical therapies, regardless of plaque location.