Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 9;168(6):990–999.e7. doi: 10.1016/j.cell.2017.02.020

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

A Model for Small RNA Production from Short DNA Fragments in Paramecium

(1) Developing macronuclear genomic DNA is targeted for excision by short RNAs. (2) Excised DNA fragments of different lengths. Blue: >200 bp, other colors: <200 bp. (3) Circularization of longer excised DNA fragments (blue), concatenation and circularization of short fragments (multicolored) by Ligase IV. (4) Bidirectional transcription to form dsRNA. (5) Cleavage of long dsRNA by Dcl5 to produce iesRNAs. (6) iesRNAs target their complementary sequences for excision in a positive feedback loop.