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. 2017 Mar 13;4(1):ENEURO.0117-16.2017. doi: 10.1523/ENEURO.0117-16.2017

Figure 2.

Figure 2.

Number of TH-positive and Nissl-positive cells in the SNpc and OD of TH-positive fibers in the STR. A, The effect of CDNF (2.5 μg) alone and GDNF (1 μg) alone, or the combination of CDNF (2.5 μg) + GDNF (1 μg) on TH-positive cell bodies in the SNpc analyzed at 12 weeks after lesion. The effect of the combination of CDNF (2.5 μg) and GDNF (1 μg) differed significantly from the vehicle-treated group (p < 0.05). B, Analyses of Nissl-stained cell bodies in SNpc. Results were in line with TH-positive cell body counts from SNpc. C, The effect of CDNF (2.5 μg) alone, GDNF (1 μg) alone, or the combination of CDNF (2.5 μg) and GDNF (1 μg) on TH-positive fibers in the STR. CDNF and the combination of CDNF and GDNF partly rescue TH-positive fibers in the STR. D, Representative TH-stained striatal sections for each treatment. Mean ± SEM in (A, B) n = 7-12 and in (C) n = 7-12 in each group. Tukey/Kramer post hoc analysis after one-way ANOVA. *p < 0.05, ****p < 0.0001.