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. 2016 Dec 29;101(4):1037–1044. doi: 10.1189/jlb.3A0916-221RR

Figure 4. IL-10+ hepatic CD8+ T cells demonstrate a high turnover rate.

Figure 4.

(A) Frequency of Ki-67–expressing hepatic CD8+ T cells among IL-10/GFP− and IL-10/GFP+ subsets, isolated from TLR9–MAS IL-10 reporter mice. Naïve and effector splenic CD8+ T cells are included for comparison. n = 4 paired samples/group. Data are representative of 2 independent experiments. Analyzed by paired Student’s t test. (B) Viability of live-sorted IL-10/GFP+ or IL-10/GFP− hepatic CD8+ T cells after in vitro culture with or without BMDCs and CpG. n = 4 paired samples/group; data were pooled from 3 independent experiments. (C) Viability time course of live-sorted IL-10/GFP+ or IL-10/GFP− hepatic CD8+ T cells or naïve splenic CD8+ T cells. *P < 0.05, ** P < 0.01.