TABLE 1.

Upstream pathway analysis and predicted regulators

Upstream regulator	Molecule type	Activation z score	P value of overlap
ESR1	Ligand-dependent nuclear receptor	5.435	6.87 × 10−12
PTGER2	G-protein coupled receptor	5.222	2.52 × 10−37
CSF2	Cytokine	4.083	4.99 × 10−31
FOXM1	Transcription regulator	3.794	4.92 × 10−13
TBX2	Transcription regulator	3.769	7.00 × 10−15
HGF	Growth factor	3.535	5.80 × 10−17
MYC	Transcription regulator	3.529	1.06 × 10−6
Vegf	Group (growth factor)	3.139	1.78 × 10−18
ACKR2	G-protein coupled receptor	3.000	1.95 × 10−8
TRIM24	Transcription regulator	2.985	1.41 × 10−5
MED1	Transcription regulator	2.945	7.99 × 10−6
MITF	Transcription regulator	2.889	6.30 × 10−12
S100A6	Transporter	2.828	4.59 × 10−8
RARA	Ligand-dependent nuclear receptor	2.820	6.56 × 10−13
AR	Ligand-dependent nuclear receptor	2.589	5.91 × 10−12
CCND1	Transcription regulator	2.496	2.16 × 10−24
AHR	Ligand-dependent nuclear receptor	2.440	2.87 × 10−5
NKX2-3	Transcription regulator	2.324	6.66 × 10−6
E2f	Group (transcription regulator)	2.204	4.90 × 10−10
MAPK1	Kinase	2.144	3.98 × 10−6
TRAF2	Enzyme	2.105	2.30 × 10−7
NUPR1	Transcription regulator	−5.864	4.50 × 10−17
TCF3	Transcription regulator	−4.359	5.46 × 10−13
TP53	Transcription regulator	−3.764	2.30 × 10−25
KDM5B	Transcription regulator	−3.733	2.86 × 10−7
IRF7	Transcription regulator	−3.533	4.59 × 10−9
IRF3	Transcription regulator	−3.412	3.79 × 10−8
CDKN2A	Transcription regulator	−3.300	4.56 × 10−7
IFNA2	Cytokine	−3.193	3.85 × 10−12
IFNAR1	Transmembrane receptor	−3.090	9.00 × 10−10
CDKN1A	Kinase	−2.715	3.89 × 10−23
TGM2	Enzyme	−2.688	3.52 × 10−7
DDX58	Enzyme	−2.608	2.46 × 10−5
BACH2	Transcription regulator	−2.607	7.22 × 10−6
IRF5	Transcription regulator	−2.353	9.86 × 10−7
SMARCE1	Transcription regulator	−2.236	3.24 × 10−5
DYRK1A	Kinase	−2.224	4.25 × 10−5
RBL1	Transcription regulator	−2.200	4.21 × 10−5
TLR9	Transmembrane receptor	−2.193	5.46 × 10−9
STAT5A	Transcription regulator	−2.081	2.32 × 10−5
IFNL1	Cytokine	−2.030	6.96 × 10−7