. 2016 Nov 11;101(4):913–925. doi: 10.1189/jlb.5MA0716-294R

TABLE 3.

IgG responses in the Ngerenya 2002 cohort, according to age group and parasitemic status

Antigens^b		Age group, yr^a		Sign.	P^c		Parasitemic status^a		Sign.	P^c
Antigens^b	All^a (n = 237)	1–4 (n = 131)	5–8 (n = 106)	Sign.	P^c	All (n = 234)^d	Apara. (n = 218)	Para. (n = 16)	Sign.	P^c
MSP1-19	0.02	0.02	0.04		0.567	0.02	0.02	0.09	^*	0.031
	[0–0.10]	[ 0–0.10]	[0–0.10]			[0–0.10]	[0.00–0.08]	[0.01–0.31]
	62 (26.2)	33 (25.2)	29 (27.4)		0.706	62 (26.5)	54 (24.8)	8 (50.0)	^*	0.039
MSP2(3D7)	0.04	0.03	0.06	^*	0.001	0.04	0.04	0.26	^*	<0.001
	[0.02–0.12]	[0.01–0.06]	[0.03–0.20]			[0.02–0.12]	[0.02–0.09]	[0.05–0.74]
	59 (24.9)	18 (13.7)	41 (38.7)	^*	<0.001	58 (24.8)	48 (22.0)	10 (62.5)	^*	0.001
MSP2(FC27)	0.02	0.02	0.03	^*	0.002	0.02	0.02	0.46	^*	<0.001
	[0–0.08]	[ 0–0.06]	[0.01–0.13]			[0–0.08]	[0.10–0.06]	[0.10–0.89]
	59 (24.9)	24 (18.3)	35 (33.0)	^*	0.009	58 (24.8)	46 (21.1)	12 (75.0)	^*	<0.001
MSP4	0.12	0.07	0.36	^*	<0.001	0.12	0.11	1.01	^*	<0.001
	[0.02–0.48]	[0.01–0.22]	[0.07–0.75]			[0.02–0.48]	[0.02–0.41]	[0.40–1.64]
	62 (26.2)	20 (15.3)	42 (39.6)	^*	<0.001	61 (26.1)	50 (22.9)	11 (68.8)	^*	<0.001
AMA1(3D7)	0.05	0.02	0.15	^*	<0.001	0.05	0.04	0.51	^*	<0.001
	[0–0.31]	[0–0.14]	[0.03–0.55]			[0–0.31]	[0.01–0.24]	[0.16–1.32]
	59 (24.9)	18 (13.7)	41 (38.7)	^*	<0.001	58 (24.8)	48 (22.0)	10 (62.5)	^*	0.001
EBA140	0.02	0.02	0		0.065	0.02	0.02	0.04	^*	0.016
	[0–0.04]	[0–0.04]	[0–0.04]			[0–0.04]	[0–0.04]	[0.01–0.23]
	60 (25.3)	31 (23.7)	29 (27.4)		0.515	60 (25.6)	52 (23.9)	8 (50.0)	^*	0.034
EBA181	0.07	0.06	0.08	^*	0.032	0.07	0.06	0.08		0.296
	[0.03–0.13]	[0.03–0.11]	0.04–0.22]			[0.03–0.13]	[0.03–0.13]	[0.05–0.32]
	61 (25.7)	23 (17.6)	38 (35.9)	^*	0.001	61 (26.1)	55 (25.2)	6 (37.5)		0.374
EBA175	0	0	0.01		0.361	0	0	0.03		0.063
	[0–0.02]	[0–0.02]	[0–0.03]			[0–0.02]	[0–0.018]	[0–0.35]
	55 (23.2)	25 (19.1)	30 (28.3)		0.095	55 (23.5)	47 (21.6)	8 (50.0)	^*	0.027
EBA140 RII^e	0.04	0.03	0.07	^*	<0.001	0.04	0.04	0.15	^*	<0.001
	[0.02–0.10]	[0.01–0.05]	[0.03–0.21]			[0.02–0.10]	[0.02–0.09]	[0.05–0.62]
	59 (25.0)	19 (14.6)	40 (37.7)	^*	<0.001	58 (24.9)	49 (22.6)	9 (56.3)	^*	0.003
EBA175-F2^e	0.16	0.12	0.26	^*	<0.001	0.16	0.14	0.67	^*	<0.001
	[0.09–0.35]	[0.07–0.20]	[0.13–0.69]			[0.09–0.35]	[0.08–0.28]	[0.34–1.18]
	59 (25.0)	15 (11.5)	44 (41.5)	^*	<0.001	58 (24.9)	46 (21.2)	12 (75.0)	^*	<0.001
RH2-2030^e	0.05	0.04	0.10	^*	<0.001	0.05	0.05	0.17	^*	<0.001
	[0.03–0.10]	[0.02–0.07]	[0.04–0.21]			[0.03–0.10]	[0.03–0.10]	0.07–0.35]
	58 (24.6)	18 (13.9)	40 (37.7)	^*	<0.001	56 (24.0)	45 (20.7)	11 (68.8)	^*	<0.001
RH4-A3	0.02	0.01	0.04	^*	0.026	0.02	0.02	0.15	^*	0.002
	[0–0.09]	[0–0.07]	[0–0.12]			[0–0.09]	[0–0.08]	[0.04–0.28]
	60 (25.3)	27 (20.6)	33 (31.1)		0.064	58 (24.8)	48 (22.0)	10 (62.5)	^*	0.001
RH4-BR^e	0.06	0.04	0.08	^*	<0.001	0.06	0.05	0.25	^*	<0.001
	[0.03–0.15]	[0.02–0.09]	[0.04–0.24]			[0.03–0.15]	[0.03–0.13]	[0.08–0.78]
	59 (25.0)	21 (16.2)	38 (35.9)	^*	0.001	59 (25.3)	48 (22.1)	11 (68.8)	^*	<0.001
Pf38^e	0.16	0.13	0.18	^*	<0.001	0.16	0.15	0.26	^*	0.013
	[0.09–0.34]	[0.07–0.31]	[0.11–0.37]			[0.09–0.34]	[0.08–0.33]	[0.15–0.48]
	59 (25.0)	29 (22.3)	30 (28.3)		0.290	58 (24.9)	52 (24.0)	6 (37.5)		0.227
Schizont extract	0.13	0.09	0.25	^*	<0.001	0.13	0.12	0.87	^*	<0.001
	[0.05–0.45]	[0.02–0.22]	[0.09–0.59]			[0.05–0.46]	[0.05–0.36]	[0.62–1.06]
	62 (26.2)	21 (16.0)	41 (38.7)	^*	<0.001	62 (26.5)	49 (22.5)	13 (81.3)	^*	<0.001

Sign., Significance.

For each antigen, represented figures reflect: median value (row 1); [p25–p75] (row 2); and high responders n (%; row 3). High responders are those with absorbance ≥75th percentile.

All alleles are 3D7 unless otherwise specified.

P values calculated using a Kruskal-Wallis test or χ² test.

Three values are missing for parasitemic status.

For these antigens, insufficient serum volume resulted in missing data for a single child who was aparasitemic and in age group 1–4 yr.

P ≤ 0.05.