TABLE 4.

IgG response among children of the Ngerenya 2002 cohort, according to parasitemia or malaria episode in the previous 6 or 12 mo^a

Antigensb (Median [p25–p75])	Parasitemic episodes (previous 6 mo)				Malaria episodes (previous 6 mo)				Parasitemic episodes (previous 12 mo)				Malaria episodes (previous 12 mo)
	0 (n = 179)	≥1 (n = 39)	Sign.	Pc	0 (n = 197)	≥1 (n = 21)	Sign.	Pc	0 (n = 116)	≥1 (n = 102)	Sign.	Pc	0 (n = 169)	≥1 (n = 49)	Sign.	Pc
MSP1-19	0.02	0.04		0.262	0.02	0.06		0.075	0.01	0.05	*	<0.001	0.02	0.05	*	0.039
	[0.00–0.08]	[0.01–0.11]			[0.00–0.07]	[0.01–0.22]			[0.00–0.05]	[0.01–0.22]			[0.00–0.06]	[0.01–0.17]
MSP2	0.05	0.06		0.052	0.04	0.06		0.285	0.03	0.06	*	<0.001	0.03	0.07	*	0.012
	[0.02–0.09]	[0.02–0.18]			[0.02–0.09]	[0.02–0.18]			[0.02–0.05]	[0.03–0.20]			[0.02–0.08]	[0.03–0.18]
MSP2(FC27)	0.02	0.05	*	0.005	0.02	0.07	*	0.007	0.02	0.03	*	0.003	0.02	0.05	*	0.008
	[0.01–0.06]	[0.02–0.11]			[0.01–0.06]	[0.02–0.12]			[0.01–0.04]	[0.01–0.10]			[0.01–0.05]	[0.01–0.10]
MSP4	0.09	0.43	*	<0.001	0.10	0.41	*	0.004	0.03	0.36	*	<0.001	0.07	0.43	*	<0.001
	[0.01–0.34]	[0.12–0.87]			[0.02–0.37]	[0.12–0.67]			[0.00–0.13]	[0.11–0.78]			[0.01–0.25]	[0.12–0.87]
AMA1	0.03	0.17	*	0.002	0.04	0.17	*	0.009	0.01	0.16	*	<0.001	0.02	0.18	*	<0.001
	[0.00–0.10]	[0.02–1.00]			[0.00–0.24]	[0.04–0.44]			[0.00–0.07]	[0.03–0.90]			[0.00–0.15]	[0.05–0.61]
EBA140	0.02	0.01		0.657	0.02	0.01		0.872	0.02	0.01		0.109	0.02	0.01		0.155
	[0.00–0.04]	[0.00–0.04]			[0.00–0.04]	[0.00–0.07]			[0.00–0.04]	[0.00–0.04]			[0.00–0.04]	[0.00–0.03]
EBA181	0.06	0.08		0.196	0.06	0.06		0.728	0.06	0.07		0.941	0.06	0.06		0.869
	[0.03–0.12]	[0.04–0.23]			[0.03–0.12]	[0.03–0.14]			[0.03–0.11]	[0.03–0.14]			[0.03–0.13]	[0.03–0.13]
EBA175	0.00	0.00		0.721	0.00	0.00		0.720	0.00	0.00		0.295	0.00	0.00		0.171
	[0.00–0.02]	[0.00–0.03]			[0.00–0.02]	[0.00–0.01]			[0.00–0.02]	[0.00–0.02]			[0.00–0.02]	[0.00–0.01]
EBA140 RIId	0.03	0.07	*	<0.001	0.03	0.09	*	<0.001	0.02	0.06	*	<0.001	0.03	0.09	*	<0.001
	[0.01–0.07]	[0.04–0.17]			[0.01–0.07]	[0.05–0.17]			[0.01–0.04]	[0.04–0.19]			[0.01–0.06]	[0.05–0.23]
EBA175-F2d	0.14	0.29	*	0.003	0.14	0.31		0.059	0.11	0.23	*	<0.001	0.14	0.19		0.054
	[0.07–0.25]	[0.12–0.54]			[0.08–0.26]	[0.10–0.55]			[0.06–0.19]	[0.13–0.57]			[0.08–0.26]	[0.10–0.54]
RH2-2030d	0.04	0.06	*	0.029	0.04	0.06		0.257	0.04	0.06	*	<0.001	0.04	0.05		0.154
	[0.03–0.09]	[0.03–0.22]			[0.03–0.09]	[0.03–0.10]			[0.02–0.07]	[0.03–0.15]			[0.03–0.09]	[0.03–0.15]
RH4-A3	0.02	0.00		0.247	0.02	0.00		0.161	0.02	0.02		0.686	0.02	0.01		0.386
	[0.00–0.08]	[0.00–0.10]			[0.00–0.08]	[0.00 0.03]			[0.00–0.07]	[0.00–0.10]			[0.00–0.08]	[0.00–0.06]
RH4-BRd	0.05	0.06		0.123	0.05	0.06		0.806	0.04	0.06	*	<0.001	0.05	0.06		0.061
	[0.02–0.11]	[0.03–0.17]			[0.03–0.12]	[0.03–0.13]			[0.02–0.09]	[0.03–0.19]			[0.02–0.11]	0.04–0.19]
Pf38d	0.14	0.17		0.362	0.15	0.17		0.671	0.12	0.18	*	0.016	0.14	0.17		0.229
	[0.08–0.33]	[0.09–0.31]			[0.08–0.34]	[0.09–0.28]			[0.08–0.25]	[0.09–0.37]			[0.08–0.32]	[0.09–0.34]
Schizont extract	0.10	0.26	*	<0.001	0.11	0.27	*	0.001	0.06	0.26	*	<0.001	0.09	0.25	*	<0.001
	[0.02–0.29]	[0.13–0.55]			[0.04–0.31]	[0.15–0.54]			[0.02–0.15]	[0.11–0.56]			[0.03–0.29]	[0.15–0.55]

Sign., Significance.

^aComparisons were made using only cohort children who were aparasitemic at the time of blood collection (n = 218).

^bAll alleles are 3D7 unless otherwise specified.

^cP values calculated using a Kruskal-Wallis test.

^dFor these antigens, insufficient serum volume resulted in missing data for a single child with no history of parasitemia or malaria episodes in the previous 12 mo.

^*P ≤ 0.05.