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. Author manuscript; available in PMC: 2017 Mar 11.
Published in final edited form as: Biochem Mol Biol J. 2017 Jan 30;3(1):2. doi: 10.21767/2471-8084.100030

Figure 2.

Figure 2

Signal pathway integration that regulates Hsp90 expression. Known signaling pathways that affect expression of Hsp90 and various scenarios for binding. Not shown is the co-activator Daxx, which is known to promote HSF1 activation. [83]. The blue rectangles represent the Hsp90 promotor regions upon which various combinations of transcription factors operate. STAT1 may function independently of HSF1 or with STAT3. IFN-γ, interferon-γ; IL-R, interleukin receptor; JAK, Janus kinase; MAPK, mitogen-activated protein kinase.