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. 2016 Nov 30;49(11):623–628. doi: 10.5483/BMBRep.2016.49.11.133

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Copyright © 2016 by the The Korean Society for Biochemistry and Molecular Biology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Gαq/11 signaling pathway mediates GPR78-regulated cell invasion. (A) Control or FLAG-GPR78 overexpressed A549 cells were transfected with Gα12/13 inhibitor p115-RGS, or Gαq/11 inhibitor GRK2-RGS, as indicated. The activation of RhoA and Rac1 was analyzed by GTPase assay. (B) shRNA-control or shRNA-GPR78#1 A549 cells were transfected with constitutive Gαq/11 protein CA-Gq, as indicated. The activation of RhoA and Rac1 was analyzed by GTPase assay. (C) The cells used in (B) were analyzed for invasion ability by Transwell migration assay. Upper panel, Representative images of Transwell assay. Lower panel, Quantitative data of migrated cells are shown. Results shown are averages ± S.E.M.