Fig. 4. ANCOVA results demonstrating main effect of CYP2A6 genotype and smoking status.
A–B) Main effect of CYP2A6 genotype, demonstrating that both the slow and intermediate genotype groups showed significantly smaller FCS in bilateral precentral gyrus and bilateral insula than the normal genotype group, regardless of smoking status. C–D) Main effect of smoking status, demonstrating that smokers showed significantly less FCS in the bilateral superior temporal gyrus than nonsmokers, regardless of genotype. L, left; R, right; PCG, Precentral gyrus; STG, superior temporal gyrus; *, Pcorrected < 0.05.