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. 2004 Nov 16;32(20):e159. doi: 10.1093/nar/gnh153

Figure 6.

Figure 6

In vivo delivery of therapeutic genes. (A) Mice hematocrit as a function of time after injection of plasmid DNA encoding inducible murine EPO either naked or complexed with 5% poloxamine 304. Tibial anterior muscles were injected with 10 μg (filled and open circles) and 30 μg (filled and open squares) of naked DNA, and with the poloxamine 304/DNA complexes containing 10 μg of DNA (filled and open triangles). Ten mice were injected in each experiment: five were treated with doxycycline (filled symbols) while the other five were not (empty symbols). Photomicrographs of tissue sections of tibial anterior muscles of mdx mice injected with naked plasmid DNA encoding the human minidystrophin-GFP (B) or the poloxamine 304/DNA complexes (C).