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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Neuroimage. 2016 Sep 11;154:43–58. doi: 10.1016/j.neuroimage.2016.09.007

Figure 10. Improved spatial specificity of cerebral blood volume (CBV)-weighted vascular space occupancy (VASO) relative to blood oxygenation level-dependent (BOLD) fMRI.

Figure 10

Human data acquired over motor and sensorimotor cortex (spatial resolution = 0.75 × 0.75 × 1.5 mm3) at 7T during alternating periods of rest (30s) and finger tapping (30s). VASO data (A) reveal signal changes that are largely localized to gray matter (white arrow), whereas the BOLD data contain more diffuse and less specific contributions across the cortex and even within the sulcus (green arrow). Both the CBV-weighted VASO and BOLD responses as a function of cortical depth (C) show expected laminar differences in hemodynamic response, however the BOLD responses are less conspicuous, likely owing to additional contributions from draining veins and cerebrospinal fluid (CSF). The error bars refer to standard deviation of the response within the activated M1 area. Data provided by Laurentius Huber; additional information can be found in (Huber et al., 2016b).