Table 1.

Summary of Metabolic Data

	Lepr^db/db	Lepr^wt/db	Lepr^wt/wt	All genotypes
CEdG (pmol/24 h)
Mean	235.0	14.9	13.9	104.1
SEM	35.1	2.4	2.3	8.7
Median	197.1	13.6	14.3	17.1
Range	23.1–543.1	2.4–131.9	1.1–99.9	1.1–543.1
N	81	71	78	230
HbA1c (%)
Mean	9.4 (80)^*	5.0 (31)	4.7 (28)	6.8 (51)
SEM	0.7 (7.3)	0.1 (1.3)	0.2 (1.7)	0.4 (4.4)
Median	9.1 (76)	5.0 (32)	4.8 (30)	5.3 (34)
Range	3.2–15.2(11–143)	3.7–5.8 (17–40)	3.5–5.7 (15–39)	3.2–15.2 (11–143)
N	27	22	15	64
FPG (mg/dL)
Mean	412.6	154.0	147.4	237.9
SEM	18.0	4.9	3.8	9.5
Median	408	143	141	164
Range	106–978	86–448	70–239	70–978
N	103	98	108	309
Mass (g)
Mean	58.5	31.0	25.0	51.9
SEM	1.8	0.6	0.5	3.4
Median	64.7	31.6	23.7	31.3
Range	28.3–89.0	24.0–37.5	21.8–30.2	21.8–89.0
N	92	76	109	277

Data representing the mean, standard error of the mean (SEM), median, range, and number of measurements (n) for each parameter over the course of 36 weeks for all animals analyzed.

Values in parentheses = mmol/mol HbA1c.