Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Shows the relation between the phosphorylation state of SPAK in vitro and the concentration of Cl−, [Cl−]. The latter is sensed through the chloride sensor motif on the WNKs that directly inhibits WNK kinase activity. Over the physiological range (highlighted in pink) WNK4 shows the greatest sensitivity to [Cl−]. KD here means kinase domain
From reference [66] with permission
