Table 2.
Effect of the KD administered for 14 days on total brain AED concentrations
| Diet | AED ED50 (mg/kg) | Brain concentration (μg/ml) | P value |
|---|---|---|---|
| SRCD | CBZ (17.7) | 4.24 ± 0.81 | >0.05 |
| KD | CBZ (17.7) | 4.27 ± 0.79 | |
| SRCD | PB (37.4) | 15.01 ± 2.05 | >0.05 |
| KD | PB (37.4) | 14.70 ± 1.99 | |
| SRCD | PHT (19.4) | 2.63 ± 0.65 | >0.05 |
| KD | PHT (19.4) | 2.40 ± 0.78 | |
| SRCD | VPA (400) | 120.6 ± 11.0 | >0.05 |
| KD | VPA (400) | 119.7 ± 15.9 |
Data are presented as means ± S.D. (N = 8) in μg/ml of brain supernatant. Statistical evaluation of data was performed with unpaired Student’s t-test. For more details see Table 2