Fig. 4.

Effect of novel peptides on anti-TSHR antibody titres. The effect of peptide therapy on time course of anti-TSHR titres, as measured by third generation ELISA. The measurements were carried out in Ad-TSHR-immunised mice treated by either four weekly injections with vehicle (“Graves’—no therapy”), or administrations of a peptide (1 mg/kg body weight—“Graves’ + peptide”). In addition, age-matched immunologically naïve mice were investigated (“healthy”). N = 10 mice were investigated in each group. Data are represented as mean ± SEM. Significance over time was tested by analysis of variance (ANOVA) of groups at given time points and controlled by ANOVA for repeated measurements within one group, followed by LSD post hoc testing. Asterisk indicates statistical significance (p < 0.05) compared to the TSHR-immunised group treated with only NaCl