Fig. 5.

Effect of peptides on macroscopically measured thyroid size. The effects of peptide therapy on thyroid sizes were investigated at the end of the experiment. The measurements were carried out in Ad-TSHR-immunised mice treated by either four weekly injections with vehicle (“Graves’—no therapy”) or administrations of peptide (1 mg/kg body weight). In addition, age-matched immunologically naïve mice were investigated. N = 10 mice were investigated in each group. The mean thyroid sizes in mm³ are shown with SEM. Differences between groups were tested by AVOVA followed by post hoc LSD testing. Asterisk indicates statistical significance (p < 0.05) compared to the TSHR-immunised group treated with only NaCl