Fig. 2.

Involvement of protein kinases in regulation of mRNA decapping processes. In human cells protein kinase JNK phosphorylates DCP1a and through this regulates P body formation. In yeast, upon glucose deprivation Ste20 phosphorylates DCP2 to stabilize its interaction with DCP1. In Arabidopsis MPK6 is activated by drought and phosphorylates DCP1, thus inducing DCP1 interactions with DCP2 and DCP5. Upon salt stress, SPI protein binds to DCP1 and facilitate its recruitment to P bodies. Phosphorylation of DCP2 and VCS is triggered by osmotic stress, but kinases functioning upstream remain still unknown. Phosphoproteomic profiling studies may suggest involvement of SnRK2 or MAP kinases in this process