Fig. 2.

Antiarthritic effect of fenoprofen in the K/BxN serum transfer model. Arthritis was induced on wild type (a–c) and Mc3r−/− (d–f) mice by two i.p. injections of arthritogenic serum on day 0 and 2. Pharmacological treatments (fenoprofen, Fen, and ibuprofen, Ibu: 10 mg/kg; vehicle: PBS) were administered i.p. twice daily from day 2. Non-arthritic mice were used as controls (Ctrl). Clinical score (a, d), paw volume (b,e) and disease incidence (c,f) were recorded over 8 days. Data are mean ± SEM of n = 5; *p < 0.05 ANOVA followed by Bonferroni multiple comparison test