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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2017 Jan 6;103:40–47. doi: 10.1016/j.yjmcc.2017.01.001

Figure 1. Experimental model and mouse survival.

Figure 1

A. Backcrossing scheme used to produce a congenic mouse strain derived from the RyR2-S2808A mouse developed in our laboratory. B. Direct sequencing of a portion of exon 55 confirms the presence of the missense mutation in codon 2808 leading to the serine to alanine substitution. Two silent mutations are located in codons 2804 and 2805. C. General scheme used to assess cardiac function in mice undergoing myocardial infarction. In this model, each mouse acts as its own control at basal conditions. D. Kaplan-Meier plot of survival after MI induction. Survival was slightly higher in S2808A than in WT controls, but this difference is not significant (n = 11–12 per genotype, p = 0.298).