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. 2016 Apr 18;52(2):697–719. doi: 10.1111/1475-6773.12492

Table 3.

Top Classes of Prescription Drug by Share of Total Drug Costs for Prescription Drug User Group, 2011 or Most Recent High‐Cost Year

Prescription Drug Class Percentage of Individuals with One or More Prescriptions Percentage of Total Prescription Drug Costs
Persistent‐HCUs (%)
Antihypertensives 72 11
Drugs for inflammatory conditions 3 8
Cholesterol drugs 57 7
Antidepressants 41 6
Antipsychotics 16 6
Acid‐reducing drugs 45 5
Drugs for respiratory conditions 26 5
Opioids 36 5
Insulins 14 4
Noninsulins 29 3
Episodic‐HCUs (high‐cost year), %
Cancer drugs 11 18
Drugs for female infertility 8 7
Antidepressants 27 4
Drugs for inflammatory conditions 2 4
Antihypertensives 25 3
Cholesterol drugs 16 3
Antipsychotics 15 2
Anticoagulants 6 2
Pregabalin and gabapentin 12 2
Antibiotics 52 2
Episodic‐HCUs (in 2011), %
Antihypertensives 18 12
Antidepressants 15 9
Cholesterol drugs 9 8
Antibiotics 36 7
Acid‐reducing drugs 10 4
Opioids 19 4
Drugs for respiratory conditions 8 3
Contraception 5 3
Benzodiazepines 14 3
Nonsteroidal anti‐inflammatory drugs 13 2
Transition from HCU (high‐cost year), %
Antihypertensives 45 9
Cholesterol drugs 31 7
Antidepressants 36 7
Acid‐reducing drugs 29 5
Antipsychotics 3 4
Cancer drugs 15 4
Drugs for inflammatory conditions 1 4
Drugs for respiratory conditions 16 3
Pregabalin and gabapentin 11 3
Opioids 28 3
Transition from HCU (in 2011), %
Antihypertensives 27 17
Cholesterol drops 14 10
Antidepressants 17 9
Acid‐reducing drugs 13 6
Antibiotics 31 5
Drugs for respiratory conditions 8 4
Opioids 17 3
Benzodiazepines 15 3
Antipsychotics 6 3
Noninsulins 6 2
Transition to HCU (%)
Drugs for inflammatory conditions 3 14
Antihypertensives 45 6
Antidepressants 34 6
Cancer drugs 5 5
Cholesterol drugs 31 5
Antipsychotics 16 4
Opioids 32 4
Drugs for respiratory conditions 19 4
Pregabalin and gabapentin 13 3
Acid‐reducing drugs 26 3
Persistent moderate‐cost user (%)
Antihypertensives 66 18
Cholesterol drugs 45 12
Antidepressants 29 8
Acid‐reducing drugs 30 6
Drugs for respiratory conditions 17 5
Drugs for inflammatory conditions 1 4
Noninsulins 17 3
Opioids 25 3
Antipsychotics 7 2
Benzodiazepines 26 2

Costs for episodic‐HCUs and transitions from HCU during their most recent high‐cost year are adjusted for inflation.