Table 1.

Time of occurrence of MxA mRNA decrease below the cut off value and the first detection of NAb positivity during the 24‐month follow‐up period

Patient (sex, age)	IFNβ	MxA↓	NAb+
M, 40	1b s.c.	M6	M6
M, 28	1b s.c.	M6	M12
M, 42	1b s.c.	M6	M18
M, 27	1b s.c.	M6	M12
F, 40	1b s.c.	M12	M12
F, 22	1b s.c.	M12	M12
F, 34	1b s.c.	M12	M18
F, 40	1b s.c.	M12	M18
F, 57	1a s.c.	M12	M12
M, 30	1a s.c.	M12	M12
F, 27	1a s.c.	M12	M12
F, 49	1a s.c.	M12	M18
F, 59	1a s.c.	M18	M18
F, 24	1a s.c.	M24	M24
M,19	1a s.c.	M24	M24

MxA↓ – MxA mRNA falling below the cut off value; NAb+ – NAb positivity. Timepoints of Nab+ /MxA↓ are given in months since initiation of IFNβ treatment (M6, M12, M18, M24). Cases where MxA↓ preceded NAbs+ are in bold.