Figure 1.

Protein expression in middle-aged (MA) (n = 12), dementia with Lewy bodies (DLB) (n = 9) and rapid DLB (rpDLB) (n = 4) of subunits of mitochondrial complexes I (NDUFFA7, NDUFA10, NDUFB10, NDUFS8, NDUFB8), II (SDHB), III (UQCRC2), IV (MTCO1), and V (ATP5A, ATP50) normalized with both β-actin- and voltage-dependent anion channel (VDAC). Three representative cases are shown in western blots. Diagrams show quantitative values of all assessed cases. Significant decrease in the expression levels of the majority of these subunits is seen in the frontal cortex in DLB and less markedly in rpDLB when compared with MA cases when normalized with β-actin and in most cases with VDAC. Decreased expression of VDAC in DLB probably reflects decrease in the number of mitochondria: *p < 0.05, **p < 0.01, and ***p < 0.001.