Figure 5.

Soluble Aβ40 and Aβ42, membrane-associated β-amyloid, tau oligomers, and α-synuclein oligomeric species in total homogenate fractions in middle-aged (MA) (n = 10), dementia with Lewy bodies (DLB) (n = 10) and rapid DLB (rpDLB) (n = 4). (A) Soluble Aβ40 and Aβ42 levels are similar in MA and DLB cases but soluble Aβ40 and Aβ42 are significantly increased in rpDLB when compared with MA and DLB; (B) membrane-associated β-amyloid is detected in DLB and rpDLB but not in MA cases as revealed with human amyloid-beta protein antibodies 4G8 and 6E10; (C) no tau oligomers are detected in DLB and rpDLB even after membrane over-exposition; (D) α-synuclein oligomers are present equally in DLB and rpDLB, which is in contrast with the lack of α-synuclein oligomers in MA. The figures are representative of four MA, four DLB, and four rpDLB; statistical values represent the totality of samples: *p < 0.05, **p < 0.01, and ***p < 0.001.