Table 3.
Summary of the main neuropathological findings of MA (cases 1–12), DLB (cases 13–21), and rpDLB cases (cases 22–25) in the present series.
| Case | Brain weight | rDLB | N loss | Astrocytosis | Microglia | Spongiosis | Diffuse plaques | Senile plaques | P-tau | Lewy bodies | Thal phase | Neurofibrillary tangle Braak stage | CERAD | ABC | Lewy body diseases stage |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Isolated | Absent | 0 | I | 0 | A0B1C0 | 0 |
| 2 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 3 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Isolated | Absent | 0 | II | 0 | A0B1C0 | 0 |
| 4 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Isolated | Absent | 0 | II | 0 | A0B1C0 | 0 |
| 5 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 6 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 7 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 8 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 9 | NA | – | Absent | Absent | Absent | Absent | Rare | Rare | Isolated | Absent | 1 | III | 0 | A1B1C0 | 0 |
| 10 | NA | – | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | 0 | 0 | 0 | A0B0C0 | 0 |
| 11 | NA | – | Absent | Absent | Absent | Absent | Moderate | Moderate | Sparce | Absent | 2 | IV | 0 | A2B2C0 | 0 |
| 12 | NA | – | Absent | Absent | Absent | Absent | Moderate | Moderate | Sparce | Absent | 2 | IV | 0 | A2B2C0 | 0 |
| 13 | 1,295 | – | Moderate | Moderate | Moderate | Mild | Frequent | Moderate | Isolated | Frequent | 4 | III | Moderate | A3B2C2 | Neocortical |
| 14 | 795 | – | Severe | Severe | Severe | Mild | Frequent | Frequent | Frequent | Moderate | 5 | VI | Frequent | A3B3C3 | Neocortical |
| 15 | 1,230 | – | Mild | Mild | Mild | Mild | Frequent | Moderate | Sparse | Moderate | 5 | V incipient | Frequent | A3B3C3 | Neocortical |
| 16 | 1,300 | – | Mild | Moderate | Moderate | Mild | Frequent | Moderate | Moderate | Frequent | 5 | IV | Moderate | A3B2C2 | Neocortical |
| 17 | 1,220 | – | Mild | Mild | Mild | Mild | Severe | Moderate | Sparse | Frequent | 4 | IV | Moderate | A3B2C2 | Neocortical |
| 18 | 1,370 | – | Mild | Mild | Mild | Mild | Absent | Absent | Absent | Sparse | 0 | I | 0 | A0B1C0 | Limbic |
| 19 | 1,280 | – | Mild | Moderate | Mild | Mild | Moderate | Moderate | Isolated | Moderate | 3 | II | Moderate | A2B1C2 | Neocortical |
| 20 | 1,365 | – | Mild | Mild | Mild | Mild | Absent | Absent | Absent | Sparse | 0 | III | 0 | A0B2C0 | Limbic |
| 21 | 1,300 | – | Moderate | Moderate | Moderate | Mild | Moderate | Frequent | Isolated | Frequent | 4 | II | Moderate | A3B1C2 | Neocortical |
| 22 | 1,120 | Yes | Moderate | Moderate | Moderate | Mild | Moderate | Moderate | Sparse | Sparse | 4 | II | Moderate | A3B1C2 | Limbic |
| 23 | 1,300 | Yes | Mild | Mild | Mild | Mild | Moderate | Moderate | Moderate | Sparse | 5 | V | Moderate | A3B3C2 | Limbic |
| 24 | 1,300 | Yes | Mild | Moderate | Moderate | Mild | Absent | Absent | Absent | Sparse | 0 | 0 | 0 | – | Limbic |
| 25 | 1,240 | Yes | Mild | Mild | Mild | Mild | Moderate | Frequent | Sparse | Frequent | 5 | V incipient | Frequent | A3B3C3 | Neocortical |
NA, not available.