Table 7.
mRNA expression levels of genes encoding cytokines and mediators of the innate inflammatory response in MA (n = 12), DLB (n = 9), and rpDLB (n = 4).
| Probes | MA | DLB | rpDLB | MA vs DLB | MA vs rpDLB | DLB vs rpDLB | |
|---|---|---|---|---|---|---|---|
| Anti-inflammatory cytokines | |||||||
| IL10 family | IL10 | 1.36 ± 0.99 | 0.70 ± 0.38 | 1.37 ± 0.97 | – | – | – |
| IL10RA | 1.13 ± 0.61 | 0.84 ± 0.29 | 1.40 ± 0.66 | – | – | – | |
| IL10RB | 1.04 ± 0.29 | 0.85 ± 0.29 | 1.24 ± 0.60 | – | – | – | |
| TGF family | TGFB1 | 1.11 ± 0.50 | 0.93 ± 0.39 | 1.40 ± 0.55 | – | – | – |
| TGFB2 | 1.08 ± 0.46 | 1.28 ± 0.46 | 1.40 ± 0.48 | – | – | – | |
| Pro-inflammatory cytokines | |||||||
| IL6 | 1.20 ± 0.78 | 1.18 ± 0.99 | 3.25 ± 2.87 | – | – | – | |
| IL6ST | 1.04 ± 0.31 | 0.92 ± 0.18 | 1.33 ± 0.44 | – | – | – | |
| IL8 | 1.12 ± 0.60 | 1.37 ± 0.83 | 1.39 ± 0.73 | – | – | – | |
| IL1β | 1.61 ± 1.57 | 1.50 ± 1.81 | 1.22 ± 0.71 | – | – | – | |
| TNFα family | TNFα | 1.14 ± 0.57 | 1.52 ± 0.51 | 4.28 ± 1.28 | – | ***↑ (0.0005) | **↑ (<0.01) |
| TNFRSF1A | 1.08 ± 0.41 | 1.57 ± 1.06 | 1.60 ± 0.84 | – | – | – | |
| Inflammation mediators | |||||||
| TLRs | TLR4 | 1.06 ± 0.38 | 1.56 ± 1.11 | 1.74 ± 0.99 | – | – | – |
| TLR7 | 1.36 ± 1.04 | 0.83 ± 0.57 | 1.21 ± 0.52 | – | – | – | |
| Colony-stimulating factors | CSF1R | 1.15 ± 0.55 | 0.80 ± 0.43 | 1.12 ± 0.29 | – | – | – |
| CSF3R | 1.24 ± 0.79 | 1.14 ± 0.65 | 2.21 ± 0.44 | – | – | – | |
| Complement system | C1QL1 | 1.04 ± 0.31 | 0.95 ± 0.27 | 1.74 ± 0.99 | – | – | *↑ (0.0366) |
| C3AR1 | 1.27 ± 0.87 | 0.97 ± 0.66 | 2.22 ± 1.61 | – | – | – | |
| C1QTNF7 | 1.15 ± 0.64 | 0.85 ± 0.37 | 0.97 ± 0.49 | – | – | – | |
| Cathepsins | CTSC | 1.37 ± 1.25 | 0.86 ± 0.54 | 0.92 ± 0.09 | – | – | – |
| CTSS | 1.36 ± 1.24 | 0.91 ± 0.53 | 1.11 ± 0.46 | – | – | – | |
| Integrin family & | ITGB2 | 1.33 ± 0.97 | 0.98 ± 0.62 | 1.73 ± 1.04 | – | – | – |
| CTL/CTLD superfamily | CLEC7A | 1.24 ± 0.76 | 0.95 ± 0.46 | 1.11 ± 0.39 | – | – | – |
| CST7 | 1.44 ± 1.17 | 2.77 ± 1.89 | 4.46 ± 1.99 | – | *↑ (0.0307) | – | |
Changes are represented with the corresponding p-value and mRNA levels are expressed as mean fold change ± SD determined by RT-qPCR and analyzed with the ΔΔCT method: *p < 0.05, **p < 0.01, and ***p < 0.001.