Table 4.
Comparative toxicity rates, overall survival and local control of selected series
| Factor | Hishikawa et al. [20] | Flores et al. [21] | Hareyama et al. [22] | Sharma et al. [23] | RTOG9207 [19] | Present study* |
|---|---|---|---|---|---|---|
| No. of pts. | 148 (66# pts) | 145 | 161 | 100 | 50 | 191 |
| BT Gy/fraction | 12/2 | 15/1 | 15-20/NS | 15-20/1 | 15/3 | 12-25/2-6 |
| ERT Gy/fraction | 60/30 | 40/15 | 47-70/25-35 | 50/28 | 50 | 40-60 |
| CT (pts) | No | No | No | Yes | Yes | 191/191 |
| Fistula (%) | 5.3 | 5 | 1.2 | 12 | 12 | 2.6 |
| Bleeding (%) | 0 | 11 | 0 | 4 | NS | 7.9 |
| Ulcer (%) | 7.1 | NS | 3 | 29 | NS | 2.6 |
| Stricture (%) | 10 | 35 | 3 | 16 | 4 | 4.2 |
| Death rate (%) | 3 | 0.6 | 0 | 4 | 8 | 0 |
| OS (%) | 37 (2 y) (66# pts) |
26 (2 y) 19 (3 y) |
43.3 – stage I (5 y), 21.1 – stage II (5 y) |
23 (5 y) | 48 (1 y) | 36.3 (3 y) |
| LC (%) | 64 (2 y) (66# pts) |
NS | 31.7% (5 y) | NS | 58 (1 y) | 75.6 (3 y) |
CT – chemotherapy, BT – brachytherapy, ERBT – external beam radiotherapy, Pts – patients, y – years, NS – not stated, OS – overall survival
#
LD – limited disease, LC – local control
*
Brachytherapy applied between EBRT