Table 1.

Total number of synonymous substitutions per codon in full-length extracellular domains and the most divergent and least divergent ectodomains from various human, coelacanth and zebrafish protocadherin paralog subgroups

Subgroup	dSECa	dSEC/branchb	dShighc	dSlowd	Ratio (dShigh/dSlow)
hα1–α13	4.68	0.20	22.29	1.56	14.29
hβ2–β15	4.64	0.17	9.41	1.27	7.40
hγA1–γA12	5.43	0.26	9.55	2.53	3.78
mα1–α12	5.40	0.26	23.90	1.34	17.77
mβ2–β22	8.02	0.21	13.63	5.77	2.36
mγA1–γA12	7.23	0.34	12.70	4.42	2.87
Dr1γ4–1γ18	5.44	0.20	14.32	0.15	94.62
Dr1γ19–1γ27	5.24	0.35	20.37	0.53	38.42
Dr2α8–2α25	9.37	0.28	33.46	0	INF
Dr2γ15–2γ31	6.02	0.19	53.32	0	INF
Lmα3-α10	3.64	0.28	4.89	2.80	1.75
Lmγ1-γ19	7.76	0.22	10.04	6.33	1.59

^aTotal synonymous substitutions per codon (dS) calculated for the alignment of full-length extracellular domain sequences for each paralog subgroup

^bThe average number of substitutions per codon for each branch in the gene tree of each subgroup

^cTotal synonymous substitutions per codon calculated for the alignment of the most divergent ectodomain in each subgroup

^dTotal synonymous substitutions per codon calculated for the alignment of the least divergent ectodomain in each subgroup