Table 1. Spearman's rank correlation of miR expression obtained with sequencing platform and progression free survival values that were statistically significant (p<0.05) with all three normalization methods: normalization via sum of reads (SOR), quantile normalization (Q) and DESeq2-normalization (DESeq2).

	Spearmans rank correlation
	SOR		Q		DESeq2
	correlation	p value	correlation	p value	correlation	p value
hsa-miR-301a-3p	−0.6907	0.0008	−0.5824	0.0143	−0.5413	0.0291
hsa-miR-423-5p	−0.6332	0.0016	−0.6230	0.0057	−0.5783	0.0169
hsa-miR-501-3p	0.4968	0.0187	0.5547	0.0193	0.5349	0.0318
hsa-miR-100-5p	0.5614	0.0082	0.5648	0.0181	0.5325	0.0318
hsa-miR-99b-5p	0.6465	0.0016	0.6836	0.0011	0.6431	0.0062

All presented miRs passed the filter of 5 reads (SOR and Q) or on average 1 read (DESseq2) for all samples. Values below 0 indicate negative correlation (the higher PFS the lower miR expression), whereas correlation >0 prove that miR expression increases with PFS values (positive correlation).