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. 2016 Oct 8;7(48):78619–78630. doi: 10.18632/oncotarget.12524

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Copyright: © 2016 Guan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Cell migration was assessed by wound-healing assay in the presence of ANO1 inhibitor or DMSO control. Images of wound closure in prostate cancer PC-3 cells treated with different concentrations of CaCC_inh-A01 (A) or T16A_inh-A01 (B) were taken at 0 h, 12 h, 24 h and 36 h. Representative images of bronchial epithelial BEAS-2B cells treated with CaCC_inh-A01 (C) or T16A_inh-A01 (D) were presented. Scale bar: 100 μm. (E–H) Bar graphs of panel A–D showing treatment of PC-3 and BEAS-2B cells with CaCC_inh-A01 or T16A_inh-A01 suppressed cell migration. Data are expressed as mean ± SEM; n = 3; ^* P < 0.05; ^** P < 0.01;^*** P < 0.001.