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U-2 OS cells were pre-treated with different concentrations of selinexor for 2 hours and then exposed to TNFα for 4 hours in serum free media. TNFα exposure induced NF-κB transcriptional activity by 10-fold. Selinexor inhibited NF-κB transcriptional activity in a dose dependent manner. The error bars indicate standard deviation and the Student's t-test was used to calculate p values. **p<0.01.
