Figure 1. Gene expression profile analysis in urinary bladder urothelial carcinoma from a published transcriptomic dataset (GSE31684).

Clustering analysis of genes regarding transmembrane receptor protein tyrosine kinase activity showed DDR2 as the most up-regulated gene with both higher primary tumor status (pT) and distal metastasis. Samples from the high pT (T2 and above, blue lines), low pT (Ta and T1, yellow lines), metastasis (purple lines), and absence of metastasis (orange lines) are shown on top of the heatmap, and the upregulation and downregulation of mRNA transcriptional level are displayed as a spectrum of brightness of red and green, respectively. The unaltered ones are coded black.