Table 1. Summary of differentially expressed genes associated with transmembrane receptor protein tyrosine kinase activity (GO:0004714) and showed positive associations to cancer invasiveness and metastasis in the transcriptome of urothelial carcinoma of urinary bladder (GSE31684).

Probe	Comparing T2–4 to Ta-T1		Comparing Meta.to Non-Meta.#		Gene Symbol	Biological Process	Molecular Function
	log ratio	p-value	log ratio	p-value
205168_at	0.6233	0.0077	0.5747	0.0018	DDR2	cell adhesion, positive regulation of cell proliferation, protein amino acid phosphorylation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein-tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
205578_at	0.6393	<0.0001	0.3795	0.0010	ROR2	JNK cascade, Wnt receptor signaling pathway; calcium modulating pathway, cartilage condensation, cell differentiation, embryonic genitalia morphogenesis, multicellular organismal development, protein amino acid phosphorylation, signal transduction, skeletal development, somitogenesis	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein-tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
225442_at	0.9193	0.0001	0.8109	<0.0001	DDR2	cell adhesion, positive regulation of cell proliferation, protein amino acid phosphorylation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding, nucleotide binding, protein-tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
227561_at	0.796	0.0011	0.7064	0.0002	DDR2	cell adhesion, positive regulation of cell proliferation, protein amino acid phosphorylation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding, nucleotide binding, protein-tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
226213_at	−2.2339	<0.0001	−0.8044	0.0036	ERBB3	heart development, peripheral nervous system development, protein amino acid phosphorylation, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway	ATP binding, epidermal growth factor receptor activity, kinase activity, nucleotide binding, protein binding, protein heterodimerization activity, protein kinase activity, protein-tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity

^#Meta., distal metastasis developed during follow-up; Non-Meta.: no metastatic event developed.