Table 3. Univariate log—rank and multivariate analyses for disease-specific and metastasis-free survivals in upper urinary tract urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival				Metastasis-free Survival
			Univariate analysis		Multivariate analysis		Univariate analysis			Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	158	28	0.8286	−	−	−	32	0.7904	−	−	−
	Female	182	33		−	−	−	38		−	−	−
Age (years)	< 65	138	26	0.9943	−	−	−	30	0.8470	−	−	−
	≥ 65	202	35		−	−	−	40		−	−	−
Tumor side	Right	177	34	0.7366	−	−	−	38	0.3074	−	−	−
	Left	154	26		−	−	−	32		−	−	−
	Bilateral	9	1		−	−	−	0		−	−	−
Tumor location	Renal pelvis	141	24	0.0079*	1	−	0.822	31	0.0659	−	−	−
	Ureter	150	22		0.712	0.200–2.538		25		−	−	−
	Renal pelvis & ureter	49	15		0.848	0.217–3.308		14		−	−	−
Multifocality	Single	273	48	0.0026*	1	−	0.010`*	52	0.0127*	1	−	0.010*
	Multifocal	62	18		2.774	1.274–6.039		18		2.569	1.480–4.460
Primary tumor (T)	Ta	89	2	< 0.0001*	1	−	0.033*	4	< 0.0001*	1	−	0.260
	T1	92	9		3.919	0.832–18.450		15		3.314	1.072–10.248
	T2-T4	159	50		5.163	1.137–23.439		51		2.729	0.969–8.580
Nodal metastasis	Negative (N0)	312	42	< 0.0001*	1	−	< 0.001*	55	< 0.0001*	1	−	0.001*
	Positive (N1–N2)	28	19		5.178	2.837–9.450		15		2.877	1.564–5.292
Histological grade	Low grade	56	4	0.0215*	1	−	0.044*	3	0.0027*	1	−	0.023
	High grade	284	57		2.964	1.030–8.534		67		3.926	1.208–12.758
Vascular invasion	Absent	234	24	< 0.0001*	1	−	0.176	26	< 0.0001*	1	−	0.008*
	Present	106	37		1.504	0.833–2.717		44		2.237	1.230–4.069
Perineural invasion	Absent	321	50	< 0.0001*	1	−	< 0.001*	61	< 0.0001*	1	−	0.008*
	Present	19	11		3.773	1.804–7.894		9		2.749	1.295–5.835
Mitotic rate (per 10 high power fields)	< 10	173	27	0.167	−	−		30	0.0823	−	−
	>= 10	167	34		−	−		40		−	−
DDR2 expression	Low	170	13	< 0.0001*	1	−	0.003	15	< 0.0001*	1	−	< 0.001*
	High	170	48		2.637	1.404–4.949		55		2.797	1.572–4.975

^*Statistically significant