. 2016 Oct 26;7(48):78918–78931. doi: 10.18632/oncotarget.12912

Table 4. Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in urinary bladder urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival				Metastasis-free Survival
			Univariate analysis		Multivariate analysis		Univariate analysis			Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male					216	41	0.4446	−	−	−	60	0.2720	−	−	−
Gender	Female		79	11		−	−	−	16		−	−	−
Age (years)	< 65					121	17	0.1136	−	−	−	31	0.6875	−	−	−
Age (years)	≥ 65		174	35		−	−	−	45		−	−	−
Primary tumor (T)	Ta					84	1	< 0.0001^*	1	−	< 0.001^*	4	< 0.0001^*	1	−	0.001^*
	T1		88	9		6.361	0.702–57.605		23		5.107	1.512–17.245
	T2-T4		123	42		27.516	2.800–218.273		49		7.401	2.173–25.205
Nodal metastasis	Negative (N0)					266	41	0.0002^*	1	−	0.182	61	< 0.0001^*	1	−	0.028^*
Nodal metastasis	Positive (N1-N2)		29	11		1.211	0.799–3.254		15		1.857	1.077–3.618
Histological grade	Low grade					56	2	0.0013^*	1	−	0.788	5	0.0007^*	1	−	0.888
Histological grade	High grade		239	50		2.066	0.172–3.805		71		1.468	0.380–3.054
Vascular invasion	Absent					246	37	0.0024^*	1	−	0.157	54	0.0001^*	1	−	0.675
Vascular invasion	Present		49	15		1.608	0.307–1.209		22		1.055	0.488–1.590
Perineural invasion	Absent					275	44	0.0001^*	1	−	0.088	66	0.0007^*	1	−	0.167
Perineural invasion	Present		20	8		2.495	0.897–4.824		10		1.791	0.803–3.548
Mitotic rate (per 10 high power fields)	< 10					139	12	< 0.0001^*	1	−	0.037^*	23	< 0.0001^*	1	−	0.034^*
Mitotic rate (per 10 high power fields)	>= 10		156	40		2.55	1.043–3.956		53		1.868	1.042–2.907
DDR2 expression	Low					147	10	< 0.0001^*	1	−	0.001^*	23	0.0001^*	1	−	0.008^*
DDR2 expression	High	148	42		3.488	1.712–7.108		53		2.006	1.203–3.345

Statistically significant.