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. 2016 Oct 27;7(48):78971–78984. doi: 10.18632/oncotarget.12978

Figure 1. NCoR represses VEGF-C and VEGF-D gene transcription NCoR represses VEGF-C and VEGF-D gene transcription.

Figure 1

(A) NCoR, VEGF-C and VEGF-D mRNA levels (means ± S.D) were measured by quantitative real-time PCR in the indicated human breast cancer cells lines and are expressed relative to the values obtained in MDA-MB-231 cells. (B) chromatin immunoprecipitation (ChIP) assays with NCoR antibody and control IgG were performed with the indicated fragments of the VEGF-C and VEGF-D gene promoters. Results obtained in two different experiments are shown. (C) levels of the indicated transcripts were determined in cells transfected with control or NCoR siRNAs 72 h before. Data (means ± SD) are expressed relative to the values obtained in cells transfected with siControl. Significance of t-test between cells transfected with siControl and siNCoR are indicated. ***P < 0.001.