Table 3. Multivariate Cox regression analysis models assessing the effects of covariates on OS in CRC patients.

Variables	(n = 509 cases)
	HR (95%CI)	P
Age (≤ 65 vs. > 65)	1.29 (0.93–1.80)	0.120
Gender (Males vs. Females)	1.50 (1.10–2.06)	0.011
Histological type (Moderate/high vs. Poor)	1.35 (0.92–1.98)	0.123
Tumor diameter (≤ 5 cm vs. > 5 cm)	1.24 (0.88–1.74)	0.209
TNM stage (I–II vs. III/IV)	1.40 (1.01–1.92)	0.041
ING4 expression (Low vs. High)	0.45 (0.29–0.71)	0.001

Abbreviations: HR: hazard ratio; CI: confidence interval.