Table 2. Survival of leukemia mice (n = 10 per group) after in vivo IL pre-activation and re-stimulation.
| Tumor cell number | Median OS (d) | Death (n) | DFS (n) |
|---|---|---|---|
| 1 × 104 | 21 | 10 | 0 |
| 1 × 104 + 1st IL | 37 | 10 | 0 |
| 1 × 104 + 2nd IL | 73 | 7 | 3 |
| 1 × 105 + 2nd IL | 64 | 10 | 0 |
| 2 × 105 + 2nd IL | 46 | 10 | 0 |
| 5 × 105 + 2nd IL | 31 | 10 | 0 |
| 1 × 106 + 2nd IL | 19 | 10 | 0 |
| Antibody neutralization | |||
| 1 × 104 + 2nd IL | 75 | 8 | 2 |
| 1 × 104 + 2nd IL + anti-IFNγ | 48 | 10 | 0 |
| 1 × 104 + 2nd IL + anti-NKG2D | 59 | 10 | 0 |
1st IL, IL pre-activation only; 2nd IL, IL pre-activation and re-stimulation ; OS, overall survival ; DFS, disease-free survival; d, day after tumor cell inoculation ; n, mouse number.