Figure 4. MSC-DF^N1IC+/+ selectively inhibit melanoma invasion and metastasis in vivo.

(A) Growth of co-grafted melanoma in mice. Top: images and weights of tumors resected from each group (n = 6/group). No significant difference in growth of tumor co-grafted with MSC-DF^N1IC+/+ vs. MSC-DF^LSL-N1IC. (B) MSC-DF^N1IC+/+ significantly diminished lung metastasis, both tumor loading in lung and % of metastasis. Metastatic foci pointed by arrowheads in lung sections were confirmed by H&E staining. (C) MSC-DF^N1IC+/+ significantly inhibit tumor invasion. Six representative images of H&E staining of tumor tissues/groups are shown. Dash lines highlight tumor boundaries. Arrowheads point to invading tumor cells. Rate of local invasion in different groups is summarized.