Table 3. Top 15 pathways (based on P value) mostly affected by the 26 miRNAs differentially expressed in the TNBC of AA and NHW groups of patients (DIANA miRPath v.2.0).
| # | KEGG pathway | P-value | # Genes | # MiRNAs |
|---|---|---|---|---|
| 1 | Neurotrophin signaling pathway | 7.39E-32 | 68 | 23 |
| 2 | MAPK signaling pathway | 1.61E-27 | 118 | 24 |
| 3 | Insulin signaling pathway | 1.15E-25 | 67 | 23 |
| 4 | PI3K-AKT signaling pathway | 3.75E-25 | 144 | 23 |
| 5 | Pathways in cancer | 3.75E-25 | 150 | 24 |
| 6 | ERBB2 signaling pathway | 1.06E-24 | 47 | 20 |
| 7 | TGF-beta signaling pathway | 2.75E-24 | 45 | 20 |
| 8 | Focal adhesion | 1.22E-23 | 92 | 23 |
| 9 | Prostate cancer | 3.45E-23 | 48 | 21 |
| 10 | GNRH signaling pathway | 5.42E-23 | 48 | 22 |
| 11 | Long-term depression | 1.37E-22 | 39 | 17 |
| 12 | Endocytosis | 1.25E-21 | 92 | 23 |
| 13 | Chronic myeloid leukemia | 1.09E-20 | 41 | 21 |
| 14 | Renal cell carcinoma | 3.06E-19 | 40 | 21 |
| 15 | Axon guidance | 3.26E-19 | 65 | 24 |
KEGG = Kyoto Encyclopedia of Genes and Genomes.