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The top 5 cytokines that were down-regulated (A) or up-regulated (B) in Huh7 cells with IGF-1R knockdown were presented compared with negative control. (C) Imaging of midkine protein array analysis in Huh7 cells. The scanning signal was weaker in Huh7 cells with IGF-1R knockdown compared with negative control (P = 0.000). *P < 0.05, **P < 0.01 versus negative control group.
