Table 2. Logistic regression analysis of association between miR-199a rs74723057 and MET rs1621 genotypes on HCC risk.
| Variants | Cases n (%) | Controls n (%) | Pa | Adjusted OR (95% CI)b | Pb |
|---|---|---|---|---|---|
| miR-199ars74723057 | |||||
| GG | 511 (49.5) | 534 (50.38) | 0.743 | 1 | |
| CG | 436 (42.2) | 448 (42.26) | 1.02 (0.77–1.35) | 0.887 | |
| CC | 85 (8.2) | 78 (7.4) | 0.97 (0.56–1.62) | 0.901 | |
| METrs1621 | |||||
| AA | 802 (77.7) | 853 (80.5) | 0.154 | 1 | |
| AG | 222 (21.5) | 195 (18.4) | 1.33 (0.96–1.85) | 0.087 | |
| GG | 8 (0.8) | 12 (1.1) | 0.24 (0.06–0.96) | 0.043 |
Note: HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval.
a
Chi-square test of genotype distribution among cases and controls.
b
Adjusted for age, sex, smoking status, alcohol use and HBV infection.