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. 2016 Nov 4;7(48):79453–79473. doi: 10.18632/oncotarget.13100

Table 6. The multiple drug design for preventing the progression of HCC from stage II and stage III based on the progression mechanism in Figure 7.

Drug molecule Target gene
celecoxib DDIT3
axitinib PDGFB
vinblastine JUN
Multiple drug molecules
graphic file with name oncotarget-07-79453-g008.jpg

The multiple drug molecules comprise celecoxib, axitinib, and vinblastine for preventing HCC from stage II to stage III. The structure of these drug molecules based on ZINC database is shown in the following figure.