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. 2016 Oct 25;7(48):79584–79595. doi: 10.18632/oncotarget.12861

Figure 1. MicroR-101 is downregulated in TMZ-resistant GBM cells and human specimens.

Figure 1

A. Dysregualted miRNAs in TMZ-resistant A172 and U251 cells identified by a miRNA PCR array representing 84 mature miRNAs associated with brain tumorigenesis. Upregulated miRNAs (miR-9, miR-182 and miR-221) were shown in red, downregulated miRNAs (miR-29c, miR-93, miR-101 and miR-130a) were shown in green. B, C. The dysregualted miRNAs were confirmed by qRT-PCR in both A172-TR (B) and U251-TR cell lines (C). D. The dysregualted miRNAs were confirmed by qRT-PCR in tumor samples obtained from matched pairs of primary and recurrent TMZ-refractory GBM patients (n=12).