Table 3. Genetic polymorphisms and outcome - univariate associations with LSCC prognosis.
SNP-ID | genotype | N(Total/Events) | Median | P-valuea | HR (95% CI) | P-valueb |
---|---|---|---|---|---|---|
rs17401966 | A/A | 125/73 | 48.0 | 1 | ||
G/A | 36/19 | 66.0 | 0.437 | 0.905 (0.545 - 1.502) | 0.669 | |
G/G | 8/7 | 35.0 | 1.576 (0.724 - 3.430) | 0.252 | ||
rs4072037 | A/A | 16394 | 46 | 1 | ||
G/A | 2/2 | 81 | 0.843 | 0.976 (0.239 - 3.985) | 0.973 | |
G/G | 3/3 | 59 | 1.403 (0.442 - 4.450) | 0.565 | ||
rs1912453 | T/T | 41/25 | 46 | 1 | ||
C/T | 113/65 | 62 | 0.389 | 0.936 (0.589 - 1.486) | 0.779 | |
C/C | 15/10 | 35 | 1.489 (0.712 - 3.116) | 0.290 | ||
rs10911251 | C/C | 45/28 | 36 | 1 | ||
A/C | 81/48 | 59 | 0.720 | 0.831 (0.518 - 1.333) | 0.443 | |
A/A | 34/19 | 66 | 0.949 (0.530 - 1.700) | 0.860 | ||
rs6687758 | A/A | 114/68 | 59 | 1 | ||
G/A | 44/26 | 44 | 0.979 | 1.047 (0.664 - 1.651) | 0.842 | |
G/G | 5/2 | 34 | 0.975 (0.238 - 4.000) | 0.972 | ||
rs11903757 | T/T | 156/88 | 59 | 1 | ||
C/T | 14/12 | 23 | 0.021* | 2.001 (1.091 - 3.673) | 0.025* | |
C/C | −/− | − | − | − | ||
rs9288520 | G/G | 92/52 | 48 | 1 | ||
A/G | 72/45 | 50 | 0.786 | 1.085 (0.727 - 1.619) | 0.691 | |
A/A | 4/2 | 22 | 0.692 (0.166 - 2.877) | 0.613 | ||
rs966423 | C/C | 111/65 | 62 | 1 | ||
T/C | 52/29 | 44 | 0.000* | 1.089 (0.701 - 1.690) | 0.705 | |
T/T | 4/4 | 5 | 7.721(2.748 - 21.695) | 0.000* | ||
rs6736997 | C/C | 105/66 | 44 | 1 | ||
A/C | 64/33 | 62 | 0.540 | 0.878 (0.577 - 1.336) | 0.543 | |
A/A | −/− | − | − | − | ||
rs975334 | T/T | 125/74 | 48 | 1 | ||
C/T | 42/25 | 46 | 0.584 | 1.017 (1.017 - 1.603) | 0.941 | |
C/C | 3/1 | 59 | 0.373 (0.052 - 2.687) | 0.328 | ||
rs8180040 | T/T | 51/32 | 44 | 1 | ||
A/T | 51/28 | 62 | 0.754 | 0.836 (0.501 - 1.394) | 0.493 | |
A/A | 43/24 | 62 | 0.858 (0.505 - 1.458) | 0.572 | ||
rs9841504 | G/G | 132/77 | 56 | 1 | ||
G/C | 26/16 | 40 | 0.680 | 1.120 (0.652 - 1.925) | 0.682 | |
C/C | 3/2 | 26 | 1.763 (0.430 - 7.223) | 0.431 | ||
rs10936599 | C/C | 48/34 | 44 | 1 | ||
T/C | 73/37 | 62 | 0.153 | 0.635 (0.398 - 1.014) | 0.057 | |
C/C | 47/28 | 36 | 0.818 (0.494 - 1.356) | 0.436 | ||
rs2239612 | C/C | 101/54 | 71 | 1 | ||
T/C | 45/31 | 40 | 0.192 | 1.488 (0.954 - 2.321) | 0.080 | |
T/T | 12/8 | 44 | 1.332 (0.632 - 2.810) | 0.451 |
Notes: P-values based on the log-rank test;
P-values based on the Wald test;
p-value < 0.05 indicates statistical significance.
Abbreviations: HR, hazard ratios; CI: confidence intervals.