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. 2016 Oct 25;7(48):79637–79653. doi: 10.18632/oncotarget.12876

Figure 2. OTX015 modulates MYC and BRD expression.

Figure 2

Figure 2

A. MYC mRNA and protein levels were reproducibly down-regulated after 72-h OTX015 exposure (100 - 1000 nM) in ALK+ cell lines by qRT-PCR and Western blot respectively. CT, DMSO-treated controls. B. 24 h exposure to OTX015 (250, 500 nM) led to dose-dependent down-regulation of MYC protein levels and G1 cell cycle arrest. β-actin was used as a protein loading control. C. 24 h exposure to OTX015 resulted in down-regulation of BRD2, BRD3 and BRD4 RNA and protein levels by qRT-PCR and Western blot. β-actin was used as a protein loading control.