Table 4. Multivariate survival analyses of patients with stage IIA, IIB, IIC and IIIA rectal cancer from the SEER database.
| Variable | Multivariate analysis | P value | |
|---|---|---|---|
| HR | 95% CI | ||
| Age at diagnosis (yrs) | <0.001 | ||
| ≤70 | 1 | reference | |
| >70 | 1.691 | 1.577-1.814 | |
| Race | <0.001 | ||
| White | 1 | reference | |
| Black | 1.402 | 1.240-1.585 | <0.001 |
| Other a | 0.753 | 0.659-0.861 | <0.001 |
| Histological Type | 0.092 | ||
| Adenocarcinoma | 1 | reference | |
| Mucinous adenocarcinoma | 1.144 | 1.009-1.298 | 0.036 |
| Signet-ring cell carcinoma | 1.228 | 0.677-2.227 | 0.500 |
| Grade of differentiation | <0.001 | ||
| Well/Moderate | 1 | reference | |
| Poor/Undifferentiated | 1.201 | 1.090-1.324 | |
| Tumor size (cm) | 1.018 | 1.009-1.028 | <0.001 |
| LNH | <0.001 | ||
| <12 | 1 | reference | |
| ≥12 | 0.720 | 0.668-0.777 | |
| TNM stage | <0.001 | ||
| IIIA | 1 | reference | |
| IIA | 1.113 | 1.003-1.235 | 0.044 |
| IIB | 1.493 | 1.267-1.758 | <0.001 |
| IIC | 2.712 | 2.319-3.171 | <0.001 |
HR = hazard ratio, CI = confidence interval, LNH = number of lymph nodes harvested.
a
Includes Native American, Asian, Pacific Islander and Unknown.