Table 1. Association and correlation of PD-L1 DNA methylation with mRNA expression and BCR-free survival.
Bead | Correlation with mRNA ( ρ, p-value) | Cox (HR, [95%CI], p-value)† | Optimized cut-off [%] | Cox (HR, [95%CI], p-value) |
---|---|---|---|---|
cg15837913 | −0.061, 0.17 | 1.01 [95%CI: 0.99-1.03], p = 0.29 | 35.845 | 2.07 [95%CI: 1.19-3.59], p = 0.010 |
cg02823866 | 0.084, 0.060 | 0.97 [95%CI: 0.61-1.54], p = 0.89 | 3.67 | 1.12 [95%CI: 0.51-2.47], p = 0.79 |
cg40305799 | 0.057, 0.21 | 0.78 [95%CI: 0.31-1.96], p = 0.59 | 1.764 | 0.68 [95%CI: 0.40-1.16], p = 0.15 |
cg13474877 | 0.032, 0.48 | 0.96 [95%CI: 0.87-1.07], p = 0.47 | 4.583 | 0.68 [95%CI: 0.32-1.45], p = 0.32 |
cg19724470 | −0.160, <0.001 | 1.02 [95%CI: 1.00-1.04], p = 0.024 | 52.75 | 2.60 [95%CI: 1.50-4.51], p = 0.001 |
mPD-L1 analyzed as continuous variable